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19th Ave New York, NY 95822, USA

PHILOSOPHY

In our research, we apply a systemic view at the process level with an interdisciplinary quantitative perspective in dialogue with the exact sciences. We are interested in the phenomena of cellular ontogeny that generate form and pattern at the tissue and organismal level, with the conviction that inter-species comparison provides a better understanding of ontogeny itself.
The experimental amenability offered by teleost fish for longitudinal in vivo studies, from the translucent embryo and larval stages to the adult, and the evolutionary diversity of this group of animals, provide a unique window of knowledge to apply our philosophy.”

SYSTEMIC

 INTERDISCIPLINE

ONTOGENIC

INTER-SPECIES

RESEARCH

Morphodynamics

We investigate how the coordinated activity of individual and collective cell groups generate form and pattern during embryo morphogenesis, with a special focus on the role of mechanics.

We use in vivo imaging, quantitative and modelling approaches in zebrafish and annual killifish embryos to extract, analyse and model in vivo information on morphogenesis.

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Asymmetry

We study how asymmetry is established in the brain during ontogeny, and the evolutionary and developmental mechanisms underlying interspecies variability in phylogeny.

We use in vivo imaging, hodological techniques and molecular approaches in the parapineal-habenular-interpeduncular circuitry of actinopterygians, with a special focus on teleost fishes.
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Lifelong
We explore how early life experiences – environmental, genetic – influence the later development of the adult and elderly animal, with special interest in nervous system health and disease.
We use different methodological approaches in zebrafish and African turquoise killifish. In the latter, we take advantage of its accelerated ageing, short lifespan and the presence of physiological neurodegeneration.
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PEOPLE

Miguel Concha

DIRECTOR

Néstor Guerrero

SENIOR LAB-TECH

Carmen G. Lemus

RESEARCH FELLOW
Morpho & Asymmetry

Patricio Ahumada

RESEARCH FELLOW
Asymmetry

Janina Borgonovo

RESEARCH FELLOW
Lifelong

Iskra A. Signore

SCIENTIFIC CONSULTANT

Fabrizio Cuevas

POSTDOC
Lifelong

Francisca Valdés

LAB-TECH

Marcos Cayuleo

MSc STUDENT
Asymmetry

Mercedes Araya

UNDERGRADUATE
Asymmetry

Karina Oyarce

PROFESSIONAL
Morphodynamics

PUBLICATIONS

  • VolumePeeler: a novel FIJI plugin for geometric tissue peeling to improve visualization and quantification of 3D image stacks. Gatica M., Navarro C.F., Lavado A., Reig G., Pulgar E., Llanos P., Härtel S., Ravasio A., Bertocchi C., Concha M.L., Cerda M. BMC bioinformatics 24 (1), 1-7 — 2023 — Read More
  • Protocol for extracting live blastoderm cells from embryos of annual killifish. Vásquez-Sepúlveda S., Guerrero N., Lemus C.G., Meynard M., Cerda M., Concha M.L., Bertocchi C., Ravasio A. STAR protocols 4 (3), 102344 — 2023 — Read More
  • A computational framework for testing hypotheses of the minimal mechanical requirements for cell aggregation using early annual killifish embryogenesis as a model. Yañez G., Skog E., Montenegro I., Dolfi L., Cellerino A., Cerda M., Concha M.L., Bertocchi C., Rojas N.O., Ravasio A., and Rudge T.J. Frontiers in Cell and Developmental Biology 20; 11:959611 — 2023 — Read More
  • Origin, form and function of extraembryonic structures in teleost fishes. Concha M.L. and Reig G. Philos Trans R Soc Lond B Biol Sci. 377 (1865), 20210264 — 2022 — Read More
  • Geometrical characterization of active contraction pulses in epithelial cells using the two-dimensional vertex model. Pérez-Verdugo, F., Reig G., Cerda, M., Concha M.L., Soto R. J R Soc Interface 19 (186), 20210851 — 2022 — Read More
  • Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism . Pulgar E., Schwayer C, Guerrero N, López L., Márquez S., Härtel S., Soto R., Heisenberg C.-P., and Concha M.L. eLife 10:e66483 — 2021 — Read More
  • KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis. Rivas, J., Diaz, N., Silva, I., Morales, D., Lavanderos, B., Alvarez, A., Saldias, M.P., Pulgar, E., Cruz, P., Maureira, D., Flores, G.; Colombo, A.; Blanco, C.; Contreras, H.R.; Jana, F.; Gallegos, I.; Concha, M.L.; Vergara-Jaque, A.; Poblete, H.; Gonzalez, W.; Varela, D.; Trimmer, J.S.; Caceres, M.; Cerda, O. FASEB J. 34 (6), 7847-7865 — 2020 — Read More
  • Optimising adjacent membrane segmentation and parameterisation in multicellular aggregates by piecewise active contours. Jara-Wilde, J., Castro, I., Lemus, C.G., Palma, K., Valdes, F., Castaneda, V., Hitschfeld, N., Concha, M.L., and Hartel, S. J Microscopy 278 (2), 59-75 — 2020 — Read More
  • Cell migration driven by substrate deformation gradients. Márquez S., Reig G., Concha M.L., Soto R. Physical Biology 16 (6), 066001 — 2019 — Read More
  • IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Urra H., Henriquez D.R., Cánovas J., Villarroel-Campos D., Carreras-Sureda A., Pulgar E., Molina E., Hazari Y.M., Limia C.M., Alvarez-Rojas S., Figueroa R., Vidal R.L., Rodriguez D.A., Rivera C.A., Court F.A., Couve A., Qi L., Chevet E., Akai R., Iwawaki T., Concha M.L., Glavic A., Gonzalez-Billault C. and Hetz C. Nature Cell Biology 20 (8); 942-53 — 2018 — Read More
  • Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish. Reig G., Cerda M., Sepúlveda N., Flores D., Castañeda V., Tada M., Härtel S. and Concha M.L. Nature Communications 8; 15431 — 2017 — Read More
  • Gastrulation in an annual killifish: molecular and cellular events during germ layer formation in Austrolebias. Pereiro L., Loosli F., Fernández J., Hartel S., Wittbrodt J., Concha M.L. Dev Dyn 246 (11); 812–826 — 2017 — Read More
  • Cell migration: from tissue culture to embryos. Reig G., Pulgar E. and Concha M.L. Development 141; 1999-2013 — 2014 — Read More
  • Computational methods for analysis of dynamic events in cell migration. Castaneda V., Cerda, M., Santibanez F., Jara J., Pulgar E., Palma K., Lemus C.G., Osorio-Reich M., Concha M.L. and Hartel S. Curr Mol Med 14, 291-307 — 2014 — Read More
  • Planar Cell Polarity signalling coordinates epithelial organ formation by regulating cell adhesion properties in progenitor cells. Oteiza P., Köppen M., Krieg M., Preibisch S., Farias C., Melo C., Pulgar E., Müller D., Tada M., Hartel S., Heisenberg C.P., and Concha M.L. Development, 137; 3459-68 — 2010 — Read More
  • Origin and shaping of the laterality organ in zebrafish. Oteiza P., Koppen M., Concha M.L. and Heisenberg, C. P. Development 135; 2807-2813 — 2008 — Read More
  • Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. Ulrich, F., Concha, M.L., Heid, P. J., Voss, E., Witzel, S., Roehl, H., Tada, M., Wilson, S.W., Adams, R. J., Soll, D. R., and Heisenberg, C. P. Development 130; 5375-5384 — 2003 — Read More
  • Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Carreira-Barbosa, F., Concha, M.L., Takeuchi, M., Ueno, N., Wilson, S. W., Tada, M. Development 130; 4037-4046 — 2003 — Read More
  • Lefty antagonism of squint is essential for normal gastrulation. Feldman, B., Concha, M.L., Saude, L., Parsons, M.J., Adams, R.J., Wilson, S.W., and Stemple, D.L. Curr Biol 12; 2129-2135 — 2002 — Read More
  • Non-canonical Wnt signalling and regulation of gastrulation movements. Tada, M., Concha, M.L. and Heisenberg, C.-P. Semin Cell Dev Biol 13; 251-60 — 2002 — Read More
  • Vertebrate gastrulation: Calcium waves orchestrate cell movements. Tada, M. and Concha, M.L. Curr Biol 11; R470-R472 — 2001 — Read More
  • Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Heisenberg, C.-P.; Tada, M.; Rauch, G.-J.; Saúde, L.; Concha, M.L.; Geisler, R.; Stemple, D.L.; Smith, J.C. and Wilson, S.W. Nature 405; 76-81 — 2000 — Read More
  • Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: a time-lapse analysis. Concha, M.L. and Adams R.J. Development 125; 983-994 — 1998 — Read More

  • Ontogenesis of the asymmetric parapineal organ in the zebrafish epithalamus. Palma K., Signore I.A., Meynard M.M., Ibarra J., Armijo-Weingart L., Cayuleo M., Härtel S. and Concha M.L. Front. Cell Dev. Biol. 10:999265 — 2022 — Read More
  • Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel. Michel L., Palma K., Cerda M., Lagadec R., Mayeur H., Fuentès M., Besseau L., Martin P, Magnanou E., Blader P., Concha M.L. and Mazan S. Front. Cell Dev. Biol. 10:1015074 — 2022 — Read More
  • Heterochrony and Morphological Variation of Epithalamic Asymmetry. Signore I.A., Concha M.L. J Exp Zool B Mol Dev Evol. 328 (1-2); 157-164 — 2017 — Read More
  • Directional asymmetry in the volume of the human habenula. Ahumada-Galleguillos P., Lemus C.G., Díaz E., Osorio-Reich M., Härtel S., Concha M.L. Brain Struct Funct. 222 (2); 1087-1092 — 2017 — Read More
  • Nodal signalling and asymmetry of the nervous system. Signore I.A., Palma K., Concha M.L. Philos Trans R Soc Lond B Biol Sci 371 (1710); 20150401 — 2016 — Read More
  • An evolutionary perspective on habenular asymmetry in humans. Concha M.L. and Ahumada-Galleguillos P. Neurol Neuromed 1 (8); 44-50 — 2016 — Read More
  • Genetics: a common origin for neuronal asymmetries? Signore I.A. and Concha, M.L. Curr Biol 24, R201-204 — 2014 — Read More
  • Daam1a mediates asymmetric habenular morphogenesis through regulating dendritic and axonal outgrowth. Colombo A., Palma K., Armijo L., Mione M., Signore I.A., Morales C., Guerrero N., Meynard M.M., Pérez R., Suazo J., Marcelain K., Briones L., Härtel S., Wilson S.W., and Concha, M.L. Development 140; 3997-4007 — 2013 — Read More
  • Encoding Asymmetry within neural circuits. Concha M.L., Bianco I.H., and Wilson S.W. Nature Reviews Neuroscience 13 (12); 832-43 — 2012 — Read More
  • Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity. Villalon A., Sepulveda M., Guerrero N., Meynard M.M., Palma K. and Concha M.L. PLoS One 7 (4); e35329 — 2012 — Read More
  • Morphologic and immunohistochemical organization of the human habenular complex. Díaz E., Bravo D., Rojas X., and Concha M.L. J Comp Neurol 519 (18); 3727-47 — 2011 — Read More
  • Mechanisms of directional asymmetry in the zebrafish epithalamus. Concha M.L., Signore I. A. and Colombo A. Semin Cell Dev Biol 20; 498-509 — 2009 — Read More
  • Zebrafish and medaka: model organisms for a comparative developmental approach of brain asymmetry. Signore I.A., Guerrero N., Loosli F., Colombo A., Villalón A. Wittbrodt J and Concha M.L. Philos Trans R Soc Lond B Biol Sci. 364; 991-1004 — 2009 — Read More
  • An Fgf8-dependent bi-stable cell migratory event establishes CNS asymmetry. Regan J.C., Concha M.L., Roussigne M., Russell C. and Wilson S.W. Neuron 61; 27-34 — 2009 — Read More
  • 3D morphotopological analysis of asymmetric neuronal morphogenesis in developing zebrafish. In Computational Modelling of Objects Represented in Images. Härtel S., Jara J., Lemus C.G., and Concha M.L. Fundamentals, Methods and Applications. Ed. João Manuel Tavares & Jorge Nata, Taylor and Francis Group, ISBN: 9780415433495, pp: 215-220 — 2007 — Read More
  • Genes as primary determinants of population level lateralization. Concha, M.L. Behavioral and Brain Sciences 28; 593-594 — 2005 — Read More
  • Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus. Aizawa, H., Bianco, I.H., Hamaoka, T., Miyashita, T., Uemura, O., Concha, M.L., Russel, C., Wilson, S.W., Okamoto, H. Curr Biol 15; 238-242 — 2005 — Read More
  • The dorsal diencephalic conduction system of zebrafish as a model of vertebrate brain lateralization. Concha, M.L. Neuroreport 15; 1843-1846 — 2004 — Read More
  • Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. Concha, M.L., Russell, C., Regan, J.C., Tawk, M., Sidi, S., Gilmour, D.T., Kapsimali, M., Sumoy, L., Goldstone, K., Amaya, E., Kimelman, D., Nicolson, T., Gründer, S., Gomperts, M., Clarke, J.D., and Wilson, S.W. Neuron 39; 423–438 — 2003 — Read More
  • Asymmetry in the epithalamus of vertebrates. Concha, M.L. and Wilson, S.W. J Anatomy 199: 63-84 — 2001 — Read More
  • A Nodal signalling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain. Concha, M.L.; Burdine, R.D.; Russel, C.; Schier, A. F. and Wilson, S.W. Neuron 28; 399-409 — 2000 — Read More
  • Immunohistochemical characterisation of the adult Nothobranchius furzeri intestine. Borgonovo J., Allende-Castro C. Medinas D., Cárdenas D., Cuevas M.P., Hetz C., Concha M.L. Cell & Tissue Research — (in press) — Read More

  • Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis. Bilches Medinas, D., Malik, S., Yildiz-Bolukbasi, E., Borgonovo, J., Saaranen, M. J., Urra, H., Pulgar, E., Afzal, M., Contreras, D., Wright, M. T., Bodaleo, F., Quiroz, G., Rozas, P., Mumtaz, S., Diaz, R., Rozas, C., Cabral-Miranda, F., Pina, R., Valenzuela, V., Uyan, O., Reardon, C., Woehlbier, U., Brown, R. H., Sena-Esteves, M., Gonzalez-Billault, C., Morales, B., Plate, L., Ruddock, L. W., Concha, M. L., Hetz, C., Tolun, A. EMBO J 41 (2), — 2022 — Read More
  • Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. Pihan, P., Lisbona, F., Borgonovo, J., Edwards-Jorquera, S., Nunes-Hasler, P. Castillo, K., Kepp, O., Urra, H., Saarnio, S., Vihinen, H., Carreras-Sureda, A., Forveille, S., Sauvat, A., De Giorgis, D., Pupo, A., Rodriguez, D. A., Quarato, G., Sagredo, A., Lourido, F., Letai, A., Latorre, R., Kroemer, G., Demaurex, N., Jokitalo, E., Concha, M. L., Glavic, A., Green, D. R., Hetz, C. Sci Adv 7 (46), eabe5469 — 2021 — Read More
  • Organization of the catecholaminergic system in the short-lived fish Nothobranchius furzeri. Borgonovo J., Ahumada-Galleguillos P., Oñate-Ponce A., Allende-Castro C., Henny P., and Concha M.L. Front Neuroanat. 15: 728720 — 2021 — Read More
  • Prion function and pathophysiology in non-mammalina models. Guerrero N., Meynard M.M., Borgonovo J., Palma K., Concha M.L., Hetz C. Curr Mol Med 17 (1); 13-23 — 2017 — Read More
  • Changes in neural circuitry associated with depression at pre-clinical, pre-motor and early motor phases of Parkinson’s disease. Borgonovo J., Allende-Castro C., Laliena A., Guerrero N., Silva H., Concha M.L. Parkinsonism Relat Disord 35; 17-24 –2017 — Read More
  • ALS-linked protein disulfide isomerase variants cause motor dysfunction. Woehlbier U., Colombo A., Saaranen M.J., Pérez V., Ojeda J., Bustos F.J., Andreu C.I., Torres M., Valenzuela V., Medinas D.B., Rozas P., Vidal R.L., Lopez-Gonzalez R., Salameh J., Fernandez-Collemann S., Muñoz N., Matus S., Armisen R., Sagredo A., Palma K., Irrazabal T., Almeida S., Gonzalez-Perez P., Campero M., Gao F.B., Henny P., van Zundert B., Ruddock L.W., Concha M.L., Henriquez J.P., Brown R.H., Hetz C. EMBO J. 35 (8); 845-65 — 2016 — Read More
  • TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Rojas-Rivera D., Armisen R., Colombo A., Martinez G., Eguiguren A. L., Diaz A., Kiviluoto S., Rodriguez D., Patron M., Rizzuto R., Bultynck G., Concha M.L., Sierralta, J., Stutzin A. and Hetz C. Cell Death Differ 19 (6); 1013-26 — 2012 — Read More
  • Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats. Dagnino-Subiabre, A., Orellana, J. A., Carmona-Fontaine, C., Montiel, J., Diaz-Veliz, G., Seron-Ferre, M., Wyneken, U., Concha, M. L., and Aboitiz, F. J Neurochem 97; 1279-1287 — 2006 — Read More
  • Hedgehog and Fgf Signaling Pathways Regulate the Development of tphR-Expressing Serotonergic Raphe Neurons in Zebrafish Embryos. Teraoka, H., Russell, C. Regan, J., Chandrasekhar, A, Concha, M.L., Yokoyama, R., Higashi, K., Take-uchi, M., Dong, W., Hiraga, T., Holder, N., and Wilson S.W. J Neurobiol 60; 275-288 — 2004 — Read More
  • Oxidative stress parameters and morphological changes in Japanese medaka (Oryzias latipes) after acute exposure to OA-group toxins. Figueroa D., Rios J., Araneda O.F., Contreras H.R., Concha M.L, García C. Life 13 (1), 15 — 2022 — Read More
  • CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues. Yu, X., Munoz-Sagredo, L.; Streule, K., Muschong, P., Bayer, E., Walter, R.J., Gutjahr, J.C., Greil, R., Concha, M.L., Müller-Tidow, C., Hartmann, T.N., Orian-Rousseau, V. Blood 138 (12), 1067-1080 — 2021 — Read More
  • Developmental Biology in Chile: historical perspectives and future challenges. Concha M.L., and Signore, I.A. International journal of Developmental Biology 65 (1-2-3), 29-47 — 2021 — Read More
  • A tale of turns and cycles guiding to neural crest migration – an interview with Roberto Mayor. Concha M.L. International journal of Developmental Biology 65 (1-2-3), 123-129 — 2021 — Read More
  • Geographic variation in the laryngeal morphology of a widely distributed South-American anuran: behavioural and evolutionary implications. López C., Quispe M., Villalón A., Concha M.L., Penna M., and Velásquez N.A. Zoological Journal of the Linnean Society 190 (1), 140-148 — 2020 — Read More
  • Toxicity and differential oxidative stress effects on zebrafish larvae following exposure to toxins from the okadaic acid group. Figueroa D., Signore A., Araneda O., Contreras H.R., Concha M., García C. Journal of Toxicology and Environmental Health, Part A. 83:573-588 — 2020 — Read More
  • The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish. Stanic K., Reig G., Figueroa R.J., Wichmann I., Opazo J.C., Owen G.I., Corvalán A.H., Concha M.L., Amigo J. Scientific Reports 9:7131 — 2019 — Read More
  • Editorial: From Ecology to Brain Development: Bridging Separate Evolutionary Paradigms. Aboitiz, F., Concha, M.L., Gonzalez-Billault, C., and Mpodozis, J. Front Neurosci 12, 447 — 2018 — Read More
  • Expression of RPRM/rprm in the Olfactory System of Embryonic Zebrafish (Danio rerio). Stanic, K., Quiroz, A., Lemus, C.G., Wichmann, I.A., Corvalan, A.H., Owen, G.I., Opazo, J.C., Concha, M.L., and Amigo, J.D. Front Neuroanat 12, 23 — 2018 — Read More
  • Ontogenia de la forma en los seres vivos. Concha M.L. Estudios Públicos (Spring 2012). 128: 211-226
  • Stem cells in development and the perspectives of celular reprogramming for regeneration. Muñoz L. and Concha, M.L. Int J Morphol 30; 1343-47 — 2012 — Read More
  • Genomic imprinting and embryonic development. Reig G. and Concha, M.L. Int J Morphol 30; 1453-57 — 2012 — Read More
  • Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer. Castillo H.A., Cravo R.M., Azambuja A.P., Simões-Costa M.S., Sura-Trueba S., Gonzalez J., Slonimsky E., Almeida K., Abreu J.G., de Almeida M.A., Sobreira T.P., de Oliveira S.H., de Oliveira P.S., Signore I.A., Colombo A., Concha M.L., Spengler T.S., Bronner-Fraser M., Nobrega M., Rosenthal N., and Xavier-Neto J. Development 137; 507-518 — 2010 — Read More
  • Functions of BarH transcription factors during embryonic development. Reig G., Cabrejos M.E. Concha M.L. Developmental Biology 302; 367-375 — 2007 — Read More
  • Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats. Dagnino-Subiabre, A., Orellana, J. A., Carmona-Fontaine, C., Montiel, J., Diaz-Veliz, G., Seron-Ferre, M., Wyneken, U., Concha, M. L., and Aboitiz, F. J Neurochem 97; 1279-1287 — 2006 — Read More
  • Expression of pcp4a in subpopulations of CNS neurons in zebrafish. Mione, M., Lele, Z., Kwong, C.T., Concha, M.L., and Clarke, J.D. J Comp Neurol 495; 769-787 — 2006 — Read More
  • Zebrafish BarH-like genes define discrete neural domains in the early embryo. Colombo, A., Reig, G., Mione, M., and Concha, M.L. Gene Expr Patterns 6; 347-352 — 2006 — Read More
  • Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway. Cavodeassi, F., Carreira-Barbosa, F., Young, R.M., Concha, M.L., Allende, M.L., Houart, C., Tada, M. and Wilson, S.W. Neuron 47; 43-56 — 2005 — Read More
  • Hedgehog and Fgf Signaling Pathways Regulate the Development of tphR-Expressing Serotonergic Raphe Neurons in Zebrafish Embryos. Teraoka, H., Russell, C. Regan, J., Chandrasekhar, A, Concha, M.L., Yokoyama, R., Higashi, K., Take-uchi, M., Dong, W., Hiraga, T., Holder, N., and Wilson S.W. J Neurobiol 60; 275-288 — 2004 — Read More
  • Combinatorial Fgf and Bmp signaling patterns the gastrula ectoderm into prospective neural and epidermal domains. Kudoh, T., Concha, M.L., Houart, C., Dawid, I.B., Wilson, S.W. Development 131; 3581-3592 — 2004 — Read More
  • Lefty antagonism of squint is essential for normal gastrulation. Feldman, B., Concha, M.L., Saude, L., Parsons, M.J., Adams, R.J., Wilson, S.W., and Stemple, D.L. Curr Biol 12; 2129-2135 — 2002 — Read More
  • Evolutionary divergence of the reptilian and the mammalian brains: considerations on connectivity and development. Aboitiz, F., Montiel, J., Morales, D., and Concha, M. Brain Res Brain Res Rev 39; 141-153 — 2002 — Read More
  • Zebrafish parachute/n-cadherin is required for neural tube closure and correct positioning of neurons within the CNS. Lele, Z., Folchert, A., Concha, M.L., Rauch, G-J., Geisler, R., Rosa, F., Wilson, S.W., Bally-Cuif, L. and Hammerschmidt, M. Development 129; 3281-94 — 2002 — Read More
  • A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Heisenberg, C.-P.; Houart, C.; Take-uchi, M.; Rauch, G.-J.; Young, N.; Coutinho, P., Masai, I.; Caneparo, L.; Concha, M.L.; Geisler, R.; Dale, T.C.; Wilson, S.W.; Stemple, D.L. Genes Dev 15; 1427-1434 — 2001 — Read More
  • Expression of nk2.1a during early development of the thyroid gland in zebrafish. Rohr, K.B. and Concha, M.L. Mech Dev 95; 267-270 — 2000 — Read More
  • Early replicating DNA involved in the G2 to M transition in allium-cepa L meristematic cells. Concha M.L., Sans J. Biology of the Cell 83; 99-103 — 1995 — Read More
  • Conduction velocity groups in the retino-tectal and retino-thalamic visual pathways of the pigeon (Columbia livia). Mpodozis J., Letelier J.C., Concha M.L., Maturana H. Int J Neurosci 81; 123-36 — 1995 — Read More

 

 

  • Origin, form and function of extraembryonic structures in teleost fishes. Concha M.L. and Reig G. Philos Trans R Soc Lond B Biol Sci. 377 (1865), 20210264 — 2022 — Read More
  • Developmental Biology in Chile: historical perspectives and future challenges. Concha M.L., and Signore, I.A. International journal of Developmental Biology 65 (1-2-3), 29-47 — 2021 — Read More
  • A tale of turns and cycles guiding to neural crest migration – an interview with Roberto Mayor. International journal of Developmental Biology. Concha M.L. International journal of Developmental Biology 65 (1-2-3), 123-129 — 2021 — Read More
  • Prion function and pathophysiology in non-mammalina models. Guerrero N., Meynard M.M., Borgonovo J., Palma K., Concha M.L., Hetz C. Curr Mol Med 17 (1); 13-23 — 2017 — Read More
  • Changes in neural circuitry associated with depression at pre-clinical, pre-motor and early motor phases of Parkinson’s disease. Borgonovo J., Allende-Castro C., Laliena A., Guerrero N., Silva H., Concha M.L. Parkinsonism Relat Disord 35; 17-24 –2017 — Read More
  • Heterochrony and Morphological Variation of Epithalamic Asymmetry. Signore I.A., Concha M.L. J Exp Zool B Mol Dev Evol. 328 (1-2); 157-164 — 2017 — Read More
  • Nodal signalling and asymmetry of the nervous system. Signore I.A., Palma K., Concha M.L. Philos Trans R Soc Lond B Biol Sci 371 (1710); 20150401 — 2016 — Read More
  • An evolutionary perspective on habenular asymmetry in humans. Concha M.L. and Ahumada-Galleguillos P. Neurol Neuromed 1 (8); 44-50 — 2016 — Read More
  • Cell migration: from tissue culture to embryos. Reig G., Pulgar E. and Concha M.L. Development 141; 1999-2013 — 2014 — Read More
  • Genetics: a common origin for neuronal asymmetries? Signore I.A. and Concha, M.L. Curr Biol 24, R201-204 — 2014 — Read More
  • Computational methods for analysis of dynamic events in cell migration. Castaneda V., Cerda, M., Santibanez F., Jara J., Pulgar E., Palma K., Lemus C.G., Osorio-Reich M., Concha M.L. and Hartel S. Curr Mol Med 14, 291-307 — 2014 — Read More
  • Ontogenia de la forma en los seres vivos. Concha M.L. Estudios Públicos (Spring 2012). 128: 211-226
  • Encoding Asymmetry within neural circuits. Concha M.L., Bianco I.H., and Wilson S.W. Nature Reviews Neuroscience 13 (12); 832-43 — 2012 — Read More
  • Stem cells in development and the perspectives of celular reprogramming for regeneration. Muñoz L. and Concha, M.L. Int J Morphol 30; 1343-47 — 2012 — Read More
  • Genomic imprinting and embryonic development. Reig G. and Concha, M.L. Int J Morphol 30; 1453-57 — 2012 — Read More
  • Mechanisms of directional asymmetry in the zebrafish epithalamus. Concha M.L., Signore I. A. and Colombo A. Semin Cell Dev Biol 20; 498-509 — 2009 — Read More
  • Zebrafish and medaka: model organisms for a comparative developmental approach of brain asymmetry. Signore I.A., Guerrero N., Loosli F., Colombo A., Villalón A. Wittbrodt J and Concha M.L. Philos Trans R Soc Lond B Biol Sci. 364; 991-1004 — 2009 — Read More
  • Functions of BarH transcription factors during embryonic development. Reig G., Cabrejos M.E. Concha M.L. Developmental Biology 302; 367-375 — 2007 — Read More
  • Genes as primary determinants of population level lateralization. Concha, M.L. Behavioral and Brain Sciences 28; 593-594 — 2005 — Read More
  • The dorsal diencephalic conduction system of zebrafish as a model of vertebrate brain lateralization. Concha, M.L. Neuroreport 15; 1843-1846 — 2004 — Read More
  • Evolutionary divergence of the reptilian and the mammalian brains: considerations on connectivity and development. Aboitiz, F., Montiel, J., Morales, D., and Concha, M. Brain Res Brain Res Rev 39; 141-153 — 2002 — Read More
  • Non-canonical Wnt signalling and regulation of gastrulation movements. Tada, M., Concha, M.L. and Heisenberg, C.-P. Semin Cell Dev Biol 13; 251-60 — 2002 — Read More
  • Asymmetry in the epithalamus of vertebrates. Concha, M.L. and Wilson, S.W. J Anatomy 199: 63-84 — 2001 — Read More
  • Vertebrate gastrulation: Calcium waves orchestrate cell Tada, M. and Concha, M.L. Curr Biol 11; R470-R472 — 2001 — Read More

— 2023 —

  • Mechanical forces as coordinators of tissue morphogenesis. Concha M.L. – Symposium “Mechanobiology in Morphogenesis, Health and Disease“. Chilean Society for Cell Biology XXXV Annual Meeting. Puerto Varas, Chile. November 6-10, 2023
  • In vivo analysis of cell migration and its relation to epiboly during gastrulation in annual killifish. Lemus C.G., Navarro C., Guerrero N., Vásquez C., Meynard M., Cerda M., Concha M.L. Chilean Society for Cell Biology XXXV Annual Meeting. Puerto Varas, Chile. November 6-10, 2023
  • Designing an interactive tool for contour-based image segmentation in bioimages. Jara-Wilde J., Cádiz M., Lemus C.G., Palma K., Valdés F., Concha M.L., Härtel S., Cerda M. Chilean Society for Cell Biology XXXV Annual Meeting. Puerto Varas, Chile. November 6-10, 2023
  • Characterisation of habenular subpopulations in Corydora paleatus. A possible case of ephitalamic symmetry. Cayuleo , Signore I.A., Lagadec R., Mazan S. and Concha M.C. Chilean Society for Neuroscience XIX Annual Meeting, La Serena, Chile. October 16-18, 2023
  • Collective effects in epithelial cell elimination. Concha M.L EMBO Workshop Cell polarity and membrane dynamics,| Sant Feliu de Guíxols, Girona, Spain. May 21–25, 2023
  • Tissue mechanics, extraembryonic epiboly and left-right patterning. Concha M.L,
  • Nothobranchius furzeri as an ageing model to study sporadic alpha-synucleinopathy. Borgonovo J., Allende-Castro C., Medinas D.B., Cárdenas D., Cuevas M.P., Hetz C. and Concha M.L. Workshop Center for Geroscience, Mental Health and Metabolism, Santiago, Chile. August 17-18, 2023.
  • Papel de fgf durante la morfogénesis temprana del órgano parapineal en pez cebra. Valdés F., Lemus C.G., and Concha M.L. Jornadas Tecnología Médica; Facultad Medicina Universidad de Chile, Santiago, Chile 2023
  • Las fuerzas mecánicas como coordinadoras de la morfogénesis tisular durante el desarrollo. Concha M.L. Seminario en Biomedicina, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. June 23, 2023
  • Epithelial delamination as a cellular plataform for coordinated tissue movement during development. Concha M.L. CIB Seminar Series, Universidad Mayor, Santiago, Chile. July 21, 2023
  • Immunohistochemical characterization of the adult Nothobranchius furzeri. Borgonovo J., Allende-Castro C., Medinas D.B., Cárdenas D., Cuevas M.P., Hetz C. and Concha M.L. 5th Nothobranchius Symposium. Leuven, Belgium. June 1-2, 2023

— 2022 —

  • Ontogenesis of the asymmetric parapineal organ in the zebrafish epithalamus. Palma K., Signore I., Meynard M., Ibarra J., Armijo-Weingart L., Cayuleo M., Härtel S. and Concha M.L. Chilean Society for Cell Biology XXXIV Annual Meeting. Puerto Varas, Chile. December 12-16, 2022
  • Computational modeling of cell aggregation identifies minimal mechanical interactions for onset of multicellularity in early annual killifish embryogenesis. Montenegro I., Yañez G., Skog E., Andaur M., Guerrero O., Dolfi L., Cellerino A., Cerda M., Concha M.L., Bertocchi C., Rojas N.O., Rudge T.J. and Ravasio A. Chilean Society for Cell Biology XXXIV Annual Meeting. Puerto Varas, Chile. December 12-16, 2022
  • Quantitative analyses of collective epithelial delamination in the early zebrafish embryo. Oyarce-Sáez K., Vásquez C., Pulgar E., Castagnini D., Palma K, Härtel S., Cerda M. and Concha M.L. Chilean Society for Cell Biology XXXIV Annual Meeting. Puerto Varas, Chile. December 12-16, 2022
  • Analysis of possible mechanical features driving early embryonic development of a. nigripinnis using engineered biomimetic environments. Vásquez S., Cardona I., Droguett M., Urra H., Guerrero N., Salas D., Cerda M., Concha M.L., Rudge T., Bertocchi C. and Ravasio A. Chilean Society for Cell Biology XXXIV Annual Meeting. Puerto Varas, Chile. December 12-16, 2022
  • Role of cadherin-6 during asymmetric morphogenesis of the parapineal organ in zebrafish. Araya M., Lemus C.G., Härtel S. and Concha M.L. Chilean Society for Cell Biology XXXIV Annual Meeting. Puerto Varas, Chile. December 12-16, 2022
  • Extraembryonic epiboly, tissue mechanics and embryo morphogenesis. Concha M.L. Institutional seminar “Mayent – Rothschild”, Institut Curie, Paris, France. October 27, 2022
  • Tissue mechanics, extraembryonic epiboly and left-right patterning. Concha M.L. Developmental and Stem Cell Biology Department Seminar, Institut Curie, Paris, France. November 4, 2022
  • Mechanical forces guide the allocation of laterality organ progenitors in zebrafish. Concha M.L. Workshop: The Biology and Physics of Left-Right Patterning, Sussex, UK. June 5-8, 2022
  • Incomplete delamination as a platform for coordinating tissue movements during development. Pulgar E., Schwayer C., Vásquez C., Oyarce K, Castagnini D., López L., Guerrero N., Palma K., Härtel S., Cerda M., Heisenberg C.P.and Concha M.L. 19th International Congress of Developmental Biology, Algarve, Portugal. October 16-20, 2022
  • A mechanism based on mechanical forces stemming from incomplete delamination guides the allocation of progenitor cells in zebrafish. Concha M.L., Pulgar E., Schwayer C., López L., Guerrero N., Márquez S., Härtel S., Soto R. and Heisenberg C.P. International Society for Stem Cell Research (ISSCR) Annual Meeting 2022, San Francisco, USA. June 15-18, 2022
  • Mechanical forces and progenitor cell allocation in embryonic development. Concha M.L. Seminars on Frontiers in Genomics 2022, Mexico (online). February 15- May 24, 2022
  • Geometric Analysis of Tissue Epithelia for Better Image Visualization and Quantification. Cerda M. and Concha M.L. 7th IEEE Workshop on Computer Vision for Microscopy Image Analysis (CVMI) 2022 at the Computer Vision and Pattern Recognition (CVPR), New Orleans, USA. June 19-24, 2022
  • Cell migration governed by durotaxis in annual killifish epiboly. Cerda M. and Concha M.L. 11th International Conference on Mathematical Modeling in Physical Sciences, Chile (online). September 5-8, 2022
  • Ontogenesis of the asymmetric parapineal organ in the teleost epithalamus. Cayuleo M., Palma K., Signore I., Meynard M., Armijo-Weingart L., Ibarra J., Härtel S. and Concha M.L. Chilean Society for Neuroscience XVIII Annual Meeting, Pucón, Chile. December 5-7, 2022

— 2021 —

  • Organization of the cathecolaminergic system in the short-lived fish notobranchius furzeri. Borgonovo J., Ahumada-Galleguillos P., Oñate-Ponce A., Allende-Castro C., Henny P. and Concha M.L. Colloqium series in cell biology: young investigators, Chile (online). November 29- December 1, 2021
  • Organization of the cathecolaminergic system in the short-lived fish notobranchius furzeri. Borgonovo J., Ahumada-Galleguillos P., Oñate-Ponce A., Allende-Castro C., Henny P. and Concha M.L. 4th Notobranchius Symposium, Czech Republic (online). June 3-4, 2021
  • Incomplete delamination as a platform for coordinated tissue morphogenesis. Concha M.L. Developmental Mechanics International Serminar Series, Israel (online). September 23–December 16, 2021
  • Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. Pulgar E, Schwayer C., Guerrero N., Lopez L., Marquez S., Hartel S., Soto R., Heisenberg C.P. and Concha M.L. International Zebrafish conference, (online). June 16-22, 2021
  • Incomplete delamination as a platform for coordinated tissue morphogenesis. Concha M.L. Society for developmental biology 80th annual meeting, (online). July 12-16, 2021

— 2020 —

  • In-silico Modelling of Cell Aggregation Dynamics of Annual Killifish Embryogenesis. Yánez G., Skog E., Montenegro I., Rojas N., Bertocchi C., Cerda M., Concha M.L., Ravasio A. and Rudge T. CCS2020 – Conference on Complex System (onlilne). December 7-11, 2020
  • Epithelial cell delamination links extraembryonic tissue spreading to progenitor cell locomotion in zebrafish. Pulgar E., Schwayer C., López L., Guerrero N., Márquez S., Härtel S., SotoR., Heisenberg C.P. and Concha M.L. From Molecules to Organs: The Mechanobiology of Morphogenesis, Singapore (online). October 30, 2020
  • Study of genetic and morphogenetic mechanisms that give rise to form, structure and functional organization during ontogenic development. Concha M.L. ANEB mini symposium talks on mechanobiology of development, Chile (online). Septiembre 21, 2020
  • Guidance of collective mesenchymal locomotion by epithelial sheet traction. Concha M.L. Developmental Biology Symposium-Quintay, Chile. January 11, 2020

— 2019 —

  • Physical model for cell migration guided by elastic properties of the substrate. Márquez S., Soto R., Concha M.L. and Reig G. 63rd Annual Meeting of the Biophysical Society, Baltimore, USA. March 19, 2019
  • Guidance of collective mesenchymal locomotion by epithelial sheet traction. Pulgar E., Márquez S., Schwayer C., Guerrero N., Härtel S., Heisenberg C.P., Soto R., and Concha M.L. LASDB Meeting, Buenos Aires, Argentina. October 30, 2019
  • In vivo guidance of cell migration by environmental mechanical cues. Concha M.L. Chilean Society for Cell Biology XXXIII Annual Meeting, Puerto Varas, Chile. November 25-29, 2019
  • Role of PrP in axonal tract formation during zebrafish neural development. Cuevas F., I Gutierrez I., Lemus C.G., Concha M.L. Chilean Society for Cell Biology XXXIII Annual Meeting, Puerto Varas, Chile. November 25-29, 2019
  • Exploring the role of PrP in axonal tract formation during zebrafish nervous system development. Cuevas F., Gutierrez I., Lemus C.G. and Concha M.L. Prion 2019: Emerging concepts, Edmonton, Canada. May 23, 2019
  • Microscopía, mecánica de tejidos y desarrollo embrionario. Concha M.L. II Congreso Nacional Biociencias, Montevideo, Uruguay. April 9, 2019
  • Forces Coordinate Morphogenesis and cell fate by driving collective cell motion in vivo. Concha M.L. Minisimposio, migracion en distintos contextos celulares; Concepción, Chile. September 1, 2019
  • Selective physical interactions drive the collective motion and spatial segregation of organ progenitors. Concha M.L 8th Biennal european Cell Mechanics Meeting, Milan, Italy. June 4, 2019
  • Nothobranchious Forzeru as a model for aging and neurodegeneration. Concha M.L. Academic Matchmaking Event, University of Groningen & Universidad de Chile; Groningen, Germany. September 24, 2019
  • Selective physical interactions drive the collective motion and spatial segregation of organ progenitors. Márquez S., Guerrero N., Schwayer C., Härtel S., Heisenberg C.P, Soto R. and Concha L. EMBO Workshop Bridging cell and tissue mechanics to fate specification in development, Santiago, Chile. April 1-5, 2019
  • Nodal signalling controls brain asymmetry by directing asymmetric cellular morphogenesis in the embryonic zebrafish brain. Lemus C.G., Jara-Wilde J., Palma K., Reig G., Marcellini S., Härtel S. and Concha M.L. EMBO Workshop Bridging cell and tissue mechanics to fate specification in development, Santiago, Chile. April 1-5, 2019
  • N-Cadherin expression and functionality during early morphogenesis in killifish embryos. Sánchez W., Farías M., Härtel S., Concha M.L. and Reig G. EMBO Workshop Bridging cell and tissue mechanics to fate specification in development, Santiago, Chile. April 1-5, 2019

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Laboratory of Experimental Ontogeny

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